For the treatment group, the antidepressant cue was compared against the placebo cue. However, the antidepressant effect was not seen in that group who received placebo for 10 to 12 months, during which time the person reported no change in their emotional basic scores. "What this study suggests is that antidepressants may cause change in the brain for those suffering from depression," says principal investigator Lalisa Katajaari.