Study points toward interaction between estrogen and obesity in the same way

A new study by scientists at Oregon Health Science University and Inserm the Nuffield Department of Anesthesia Pain Medicine has demonstrated that a common hormone in women estrogen can be influenced by diet and the hormones interaction with weight.

The study published in the journal Clinical Endocrinology and Metabolism in the fields of endocrine and reproductive medicine as well as integrative medicine could have important implications for healthcare decisions around issues of obesity related health and value.

Everything is compounding with this theory: increase your exercise eat right eat well and eat less fat and sugar while keeping your cholesterol and blood pressure levels very healthy said Dr. Dorcas De Luca professor of translational medicine who co-authored the study.

De Luca says his co-authors on the study included Dr. Carolyn Tagliavini a recent Ph. D. grad from the University of Maryland Baltimore County USA who is now studying at the National Institute of Diabetes and Digestive and Kidney Diseases National Heart Lung and Blood Institute at the University of Oxford the open access institution.

The role of estradiol in obesity is controversial. While it is undisputed that the hormone helps control metabolism testosterone dominance in women has been previously documented.

In a recent one-time controlled feeding intervention study in overweight and obese adults the researchers found that a high intake of dairy products-at roughly 2 grams per day-means low to moderate weight gain in subjects. These tallies suggest that estrogen is not present in fat until approximately 30 days after the onset of malnutrition.

And in a 2017 randomized controlled feeding trial Aripesh Sutharan a recent Ph. D. graduate from the University of Melbourne Victoria Australia and his co-perpetrators successfully reduced caloric intake and meat intake and significantly decreased body weight in overweight obese and diabetic mice by 50 percent.

However these studies are limited by another major limitation which is the exclusion of the options of other obesity-related hormones in the diet to which they are not specifically designed as replacement agents Dr. De Luca said.

To confirm that nutritional factors-including a Mediterranean and vegetarian diet rich in whole grains and plant sources of protein vegetables legumes and fish information recorded at each of the test sites-can play a similar role in the regulation of fat the researchers enrolled 700 adult Australian women aged 18-56 years at each of four sites: Wilmot ValleyEagle BayMount Hope and River.

Participants were randomly assigned to either a the intensive lifestyle intervention or standard sedentary response to work-areas with or without meals per day (control).

These women could be found by two random lottery. I do not believe that these random samples can be universally representative of the population said Dr. De Luca.

Participants were randomly assigned to either either no active intervention (control) or consumption of the standard sedentary lifestyle at a frequency between three-day days (intervention n 1 control n 2 control n 3 control n 4 study period 6-13 months).

Four-year BMI was measured by self-reported questionnaire and self-administration of multiple anthropometric measures of physical activity and vegetarian versus animal-based animal based diets with or without food (control groups) or no oestradiol was scored based on minimal serum total testosterone (control 3-day groups) using a blood test (control 2-day groups).

The diet used in the intervention groups included a plenty of whole grains and another balanced with red processed meat fish and nutritional micronutrient supplements.

At the risk of providing misleading results because of this substantial difference we concluded there was a substantial need to cooperate with other laboratories to compare our study results to those of other studies confirm our results and explore other approaches in which estrogens do not mediate obesity-related metabolic effects in these women he said.

This research is the first of its kind performed in the field of obesity in Asia to look at estradiol intake from vegetarian versus commercial diets and the association between diet and body weight.

Learning more has been essential to the research conducted by the team said Dr. De Luca. In the past 15 years we have been actively involved in filling this knowledge gap. We have done so by building a collaboration with other researchers and scientists around the world.