Because of their unique vulnerability schizophrenia is thought to manifest 15-20 years before the appearance of commonly thought-of symptoms when auspices may run out for importance such as friendship parties and marriage.
Southwestern psychiatrists at the University of California Los Angeles have completed the largest ever study of the genetic causes of schizophrenia and tested how the states gene mutation rates have changed over 55 years.
We have a statistical model that weve built to predict the likelihood with larger numbers of schizophrenia-confounding genes being present said Professor Richards from the USC Institute of Neurosciences who co-directed the study along with Professor Robert Stein of the University of California San Francisco. The research team also included experts from Georgia State University and from Columbia University in the United States and Spain.
The article Association of gene mutations and schizophrenia-like genes in California and genes associated with overactivity in schizophrenia will be published in the April 15 edition of Molecular Psychiatry.
They believe thes work-the S5 Professional Study-will advance the field of gene mutations genetic understudied mechanisms of disease susceptibility and research into potential therapeutic interventions.
Gene mutations that predispose patients to develop schizophrenia include the mutations of the Structural Neurobiology of Schizophrenia 2 (SNTR2) gene. SNTR2 targets a large portion of the third major gene region known as the neurexin protein.
SNTR2 works in the cell: It gets enzymes and enzymes moving around and is regulated by growing neurons said MPH Professor Richards in commenting on the studys importance. There is no cure for schizophrenia which often begins before the age of 15.
Principle Investigator Dan Atheyrede MPH and his colleagues compared known schizophrenia-related gene mutations with schizophrenia and SNTR2 mutation rates.
In addition to genetic exposure and developmental risk the researchers looked at the mood disorders conduct disorders concentration disorders personality disorders and personality traits.
Of the 55 cases 21 or about 1. 5 percent had schizophrenia-like symptoms. An additional 14 had mood disorders related to positron emission 0-Receptor antiprotein (PET) PET defects.
To assess their relationship the team used a neuropsychological test the Brief Psychosocial Stress Inventory (5 points) – which assesses depressive symptoms and above-normal mood related to everything from work to relationships social interactions and social behavior.