Zu Av Cheong, led by IU researcher, aims to make mouse models of Alzheimer’s disease

There is considerable excitement about the use of regenerative medicine to treat neurodegenerative diseases, such as Alzheimer’s disease. A common problem in these drugs is resistance. Research groups led by IU are developing a model system that can be used for producing Alzheimer’s disease-like proteins which have the potential for performance in the clinic.

A major goal of biomedical engineering research is to apply engineering principles to create better products. Demanding research facilities like the INSPIRE program have thus far not only produced valuable insights about the cellular and molecular mechanisms involved, but also contributed to efforts to optimize cellular engineered proteins.

For example, the team led by Ian C. Cheong, hindered their way to deliver 3D proteins for dendritic arbors, a structure where Aβ, CBG and other proteins join in the cell. Prototypes with this application are already being tested in animal models of dementia-like disease.

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Serious methodological difference.

One of the major differences between the rats and the human models is cell nature. To the best of our knowledge, this is the first instance that this model universe has been considered using amyloid biopsies to model rodent amyloid beta deposition in the brain. “Insulin sensitivity” is extremely responsive to amyloid deposition, one of the main pathological pathological changes associated with AD. “3D bioprinting” has effectively been utilized for the microtubule bioprinting.